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eClin Med 58:1 Henn RE, Noureldein MH, Elzinga SE, Kim B, Savelieff MG, Feldman EL (2022) Glial-neuron crosstalk in health and disease: a focus on metabolism, obesity, and cognitive impairment

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That said, the clinical evidence for routine 5-MTHF in over-35s without an MTHFR polymorphism remains limited, and folic acid at the 400 g dose remains the guideline-backed default

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