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Waiting even 10-15 minutes significantly reduces absorption as the skin's barrier function begins restoring

Commonly used phospholipids in these nanostructured vesicles include phosphatidylserine, phosphatidylcholine, hydrogenated phosphatidylcholine, phosphatidic acid, phosphatidylethanolamine, phosphatidylglycerol, and phosphatidylinositol [129]

[PubMed ID: 29783098]

With that regulatory brake reduced, IGF-1 LR3 interacts with IGF-1 receptors more directly and for a longer duration, which is why research protocols report a half-life of roughly 2030 hours, compared to native IGF-1s 1215 hours