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The molecular-level understanding of OA pathogenesis has led to the identification of major catabolic enzymes, ADAMTS5 76 , MMP3 77 , and MMP13 78 , which mediate the degradation of cartilage matrix

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Before bariatric surgery is approved, patients must undergo comprehensive assessment by a multidisciplinary team including surgeons, dietitians, and psychologists within Tier 3 specialist weight management services