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In order to investigate this, a two-phase model of APAP toxicity in freshly isolated hamster hepatocytes was developed;25 in phase 1, metabolic activation of APAP occurred with depletion of GSH, but no loss of cell viability

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Mechanistically, ART suppressed nuclear localization of SREBP2 in MM cells, accompanied by downregulation of IPP and GPX4, suggesting its capacity to trigger ferroptosis through SREBP2 nuclear localization inhibition and subsequent IPP/GPX4 suppression (Liang et al., 2023)

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