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This action leads to a reduction in intracellular GSH levels, resulting in increased oxidative stress, which induces apoptosis and cell cycle arrest

Other long-term toxicities Beyond the aforementioned target organ toxicities, long-term cohort studies have confirmed that platinum-based chemotherapy induces multiple delayed long-term adverse outcomes (manifesting years to decades post-chemotherapy, severely impairing cancer survivors long-term survival), including reproductive toxicity, cardiovascular toxicity, and elevated second primary neoplasm (SPN) risk

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[DOI] [PubMed] [Google Scholar] 37.Costantini P, Jacotot E, Decaudin D, Kroemer G