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At experimentally suitable concentrations (up to 100 M), we observed the appearance of Chc bound to three peptides and, although in much lower amounts, a fourth binding event was also detected (Supplementary Fig

Regular follow-ups and tests monitor progress, adjusting treatment as needed

In experimental models, it appears to interact with several pathways central to tissue integrity and repair

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In addition, intestinal epithelial cells (IECs), otherwise known as enterocytes, are adjoined by TJ complexes that are further tethered to an intracellular cytoskeleton permitting communication across the epithelium and regulating processes including the cell cycle (Brenchley and Douek 2012)