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Teismann, P

Arginine equivalent roughly 3 g of citrulline behaves like 6 g of arginine for plasma levels

That decision is made carefully

So with these regulatory insights, it seems like there is a need for broader systemic changes

These findings highlight the complexity of metformins effects, which may be age-, genotype-, and disease-context dependent, reinforcing the need for further experimental and clinical validation to clarify its therapeutic potential and risks in AD prevention across different populations