glp-1 and hs Gut Health: Addressing Metabolic Dysfunction for Physicians The Therapeutic Potential of GLP-1

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Astrocytes convert network excitation to tonic inhibition of neurons

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The mutual outcome of these two effects is the upregulation of hepatic BA formation and emission of conjugated BAs into the blood circulation, which distally anchors the FXR in the bone marrow, resulting in the loss of osteoblast function, negatively impacting BMD, bone volume fraction, and fracture resistance (115)