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Any temperature excursion above 8C for more than 24 hours risks peptide degradation that home testing cannot detect

Neurological recovery, if present, can take longer and may not fully reverse if deficiency was severe and longstanding

Since it is hard to obtain clinical samples in overdose cases that control the many genetic and environmental variables that can affect protein expression, it is often easier to discover proteomics biomarkers in nonclinical toxicity studies and then set up clinical sample collection strategies to further evaluate the potential toxicity biomarkers

However, B12 shots can lead to side effects including: - Headache - Dizziness - Diarrhea - Skin rash and itching - Nausea and vomiting - Fatigue - Swelling and tingling sensation Additionally, excess vitamin B12 can also result in rare but severe allergic reactions also known as anaphylaxis