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This process is facilitated by lysosomal iron release and its uptake into mitochondria, resulting in the induction of the mitochondrial permeability transition and ultimately hepatocyte necrosis

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Cureus 14(10):e30812 Hogan AE, Gaoatswe G, Lynch L, Corrigan MA, Woods C, OConnell J et al (2014) Glucagon-like peptide 1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus