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This very low dose was well tolerated but produced less weight loss than higher doses

But dismissing these effects or failing to plan for them is one of the fastest ways to derail a protocol

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This is the first Phase 3 GLP-1-class readout that specifically demonstrates symptomatic benefit in knee osteoarthritis beyond what would be expected from weight loss alone, and it opens the possibility, still to be confirmed in dedicated trials, that GLP-1 receptor signaling has direct anti-inflammatory or disease-modifying effects on joint tissue

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