if switching from semaglutide to tirzepatide Tirzepatide: Reasons, Safety & Dosage for Weight Loss Switching From Tirzepatide to Semaglutide:

The negative attitude of Novo Nordisk was summed up by Lars Srenson, the company's CEO, who in 2005 argued 'Obesity is primarily a social and cultural problem

37 Similarly, in a retrospective cohort study of 3435 people with type 2 diabetes exposed to tirzepatide for 180 days and over compared with a matched unexposed cohort, tirzepatide was associated with an increased risk of new-onset proliferative diabetic retinopathy primarily in those with pre-existing nonproliferative diabetic retinopathy

Biol Trace Element Res (2015) 167(2):1949

This reaction occurs as fluid accumulates in the tissue where the needle was inserted

And GLPs are not recommended in patient populations with: severe gastrointestinal diseases such as gastroparesis and inflammatory bowel disease