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Hence, there are at least two distinct mechanisms for regulating IGF-1R activity in response to a cells mechanical loading state

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Application: Subcutaneous injection (systemic, not directly into scalp) Dosing: Loading phase: 5-10mg per week (split into 2-3 injections), 4-6 weeks Maintenance: 2-5mg per week ongoing Timeline: Hair changes typically noticed 2-4 months after starting

Additionally, NTHi strains deficient in the ability to acquire haemoglobin-haptoglobin have an attenuated ability to cause infection (Seale et al., 2006)

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