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In addition, as recombinant hHGF has been used for the differentiation of induced pluripotent stem cells into hepatocytes 33 , an appropriate replacement of hHGF with the dimeric macrocycles that are chemically synthesized assures no biological contaminants of organismal origin

if storage of reconstituted material is necessary, aliquot into single-use volumes and keep at -80 C to minimize freeze-thaw degradation

Moreover, an open channel is present at the 2-fold axes in wtVLP, while this channel is sealed in sVLP (Fig