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If injection frequency is a concern, MK-677 remains viable, but expect to fight more food cravings

Hepatic enzymes (cytochrome P450 oxidases, glucuronosyltransferases) metabolise and conjugate the compound, reducing the amount that reaches target tissues

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The actions of GLP-1 and GIP on glucagon secretion are different, since GLP-1 suppresses glucagon [63] during hyperglycemia [64,65,66], but not at a normal fasting plasma glucose concentration [65]