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A total of 4 10 HOXC8-imESCs or Control-imESCs suspended in serum-free medium were added to the upper chamber of the culture insert, while 750 l of medium containing 10% FBS was placed in the lower chamber of a 24-well plate and incubated for 24 h

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The principal research objective of this multicenter double-blinded randomized placebo controlled trial was to determine the dose required to achieve physiological melatonin blood levels in preterm infants, similar to that of the mother and to define its pharmacokinetic profile in preterm infants

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