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Example-15: Cleavage and global deprotection to prepare Semaglutide backbone Resin bound Semaglutide backbone (50 gm) was slowly added to a pre-cooled mixture of TFA (332 ml), TIS (20 ml), phenol (40 ml) and water (8 ml) at 10-15C and stirred the reaction mixture for 15 min at the same temperature

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