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Normal levels of GSH have been shown to have roles in restricting serine availability to preserve regulatory T cell (Treg) functionality (Kurniawan et al., 2020)

Approaches to gene modulation therapy for ALS

Ischemic stroke is the most prevalent type of stroke and is characterized by a myriad of pathological events triggered by an arterial occlusion that can eventually lead to fatal outcomes such as hemorrhagic transformation (HT)

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The relative contribution of GSTP1 to GSH-conjugation of both QIs was highest at GSH-depleted conditions, while in absolute quantities a higher GSTP1-dependent increase of GSH conjugate formation was seen without BSO pre-treatment ( Figure 5 )