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2012), our observation that APAP decreased GJ abundance suggested that hepatocytes mount a defense against the spread of oxidative stress molecules within liver tissue during the early stages of APAP exposure by reducing the expression of Cx32 (and consequently GJs)

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Ferroptosis, a recently discovered iron-dependent form of nonapoptotic cell death, has been associated with neurodegeneration and p53-mediated tumour suppression 28,29