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However, along with the rapid titration schedule came gastrointestinal side effects, especially nausea and vomiting, which were the most common reason for discontinuation
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Sweeney et al., 2018)
Overlapping binding sites of GLP-1 and Fab 3F52 The -helix of the GLP-1R ECD is a critical part of the GLP-1 binding site as shown previously by x-ray crystallography and it is also the primary binding site of Fab 3F52 as shown in this study 31
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