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Alcohol intake, operant alcohol self-administration, alcohol preference, alcohol-induced CPP, and alcohol-induced nucleus accumbens dopamine release have been found to be reduced in ghrelin or GHSR knock-out mice and rats [12, 14, 19, 20] and by pharmacological GHSR antagonism [12, 15,16,17,18, 21,22,23,24,25]

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Mild nausea at the start of GLP-1 therapy is common, but pain or persistent GI symptoms after dose stabilization require clinical investigation to rule out pancreatic involvement

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Brand-name vials through the manufacturers self-pay program may cost $349 to $499 per month for eligible patients