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Wipe the vial top with a fresh alcohol swab before every puncture, use a new sterile needle each time, and discard the vial 28 days after first puncture

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The clinically important interactions are with insulin and sulfonylureas (high hypoglycemia risk), warfarin (INR monitoring needed), oral contraceptives (slight absorption change), levothyroxine (timing matters), and antibiotics that require precise blood levels

This review explores the mechanisms of action, clinical efficacy, and safety considerations of GLP-1 receptor agonists and SGLT-2 inhibitors in obesity management and the associated cardiovascular complications