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However, in people with T2D and MASLD, 24 weeks of efinopegdutide 10 mg reduced liver fat content by 72.7% compared to 42.3% reduction with semaglutide 1 mg despite similar WL achieved with both interventions [79]

Reported side effects are similar to other incretin-based therapies and may include nausea, digestive discomfort, or fatigue during dose titration

The pharmacokinetic profiles vary among different agents, with some administered daily and others weekly

GLP-3RT (retatrutide) The primary retatrutide offering from Simple Peptide is marketed under the designation GLP-3RT

Methodology This survey was commissioned by Sunlight.com in September 2025 and conducted through Pollfish