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Coverage is improving but usually depends on meeting criteria such as BMI or related health conditions

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Surgical excision can be considered for cellular blue nevi that are difficult to follow due to location or topography

While classical gene mutations are region-limited, epimutations often occur early in cancer development and have a genome-wide impact, boosting on the one hand the expression of cell survival genes or proto-oncogenes and deactivating on the other hand tumor suppressor genes (TSGs), DNA repair mechanisms as well as cell division brakes, thus leading to carcinogenesis (Karius et al., 2012