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If neurological symptoms worsen or fail to improve after four to six weeks of appropriate treatment , further investigation is necessary to exclude alternative diagnoses or complications

However, this finding was consistent with previous reports showing that CCP1-2 domains contain the binding site on C4bp to many pathogens ( We have also shown that an antibody response against the NTD, containing the C4bp binding motif (Pep1), was undetectable if mice were immunized with FL-CSP suggesting that the repeating identical immunogenic determinants within the central repeat domain can mask immune responses to other CSP domains