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We're going to compare adolescents and adults and bring in the science of brain plasticity

14,16 In the brain, GLP-1RAs bind to receptors in the hypothalamus to promote satiety and reduce food intake

We have used glucose sensors for our patients with RH when pharmacological interventions have reached their ceiling effect, although this is currently off-label ( We acknowledge limitations to our conclusions resulting from the case series design

Trial FLOW (Perkovic et al., NEJM 2024) Design Phase 3 / event-driven Population 3,533 adults with T2D and CKD Key result 24% reduction in kidney disease progression and CV death (HR 0.76

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