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doi: 10.1016/j.bjorl.2017.08.012 74 GraceffaGPatroneRVieniSCampanellaSCalamiaSLaiseIet al

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The common interactions involve two salt bridges with glutamic acid residues at positions 6.53b and 7.42b via the positively charged N-terminal nitrogen atom of tyrosine 1, stacking interactions with tryptophan residues via phenylalanine 22, and multiple hydrogen bonds with various conserved residues across all three receptor subtypes [3]

Additionally, two studies utilized a 5-state Markov model structure [24, 26]