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Metabolic comorbidities are highly prevalent and bidirectionally linked to MASLD: type 2 diabetes, hypertension, dyslipidemia, and chronic kidney disease (CKD) cluster together, collectively amplifying hepatic and systemic disease progression

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For example, a person with chronic granulomatous disease (CGD) may have difficulty fighting fungal and bacterial infections whereas a person with common variable immunodeficiency disease (CVID) is prone to infection from flu strains, pneumonia, and streptococcus pneumonia

Ultimately, inflammasome activation and IL-1 production lead to extracellular matrix deposition and kidney fibrosis 91,92

FAQ What is reduced L-glutathione and what does it do