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The primary analysis included 66,102 participants, and a sub-group analysis focused on 3,313 individuals who were newly initiated on either GLP-1 RAs or insulin as second-line treatment

This comprehensive synthesis underscores the shift toward a mechanistic, individualized approach to OA management and identifies key translational opportunities for disease modification and early intervention

2019), suggesting partial conservation of GLR-NO coupling

Glutathione works within an "antioxidant network" where different nutrients help regenerate each other

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