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Neurons and microglia can detect and sense cytosolic mtDNA, driving neuroinflammatory responses characterized by cytokine production, inflammasome activation, and recruitment of peripheral immune cells [12]

Mechanistically, IF reduces systemic inflammation, alters the distribution of adipose tissue, and increases thermogenesis, which in turn supports insulin signaling pathways and enhances metabolic flexibility [49]

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Most peptide programs are designed as ongoing monthly protocols