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Figure 2 Discussion A number of studies have suggested the important role oxidative stress plays in the pathophysiology of MS, and that markers of oxidative stress are increased in MS lesions (31, 32)

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Among them, compound 8u becomes the most effective xanthine oxidase inhibitor, with an IC50 value of 0.0288 mM, which is equivalent to febuxostat (IC50 0.0236 mM) (Zhang et al., 2019)