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Retatrutide is an investigational triple incretin receptor agonist with no current regulatory approval, while tesamorelin is a GHRH analogue licensed in the US for HIV-associated lipodystrophy but unlicensed in the UK

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[5] [10] By activating the GLP-1 receptor, retatrutide is thought to stimulate insulin secretion in a glucose-dependent manner, suppress glucagon release, and reduce appetite

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Most common side effects of retatrutide The most commonly reported side effects were related to digestion