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For instance, in the subarachnoid hemorrhage model, bromodomain-containing protein 4 (BRD4) was found to bind to H4K8la in astrocytes, and its expression silencing significantly affected the level of this modification, suggesting that BRD4 may serve as a potential reader of H4K8la under this pathological context (Zhang F
Peripheral infusion of GLP-1 decreases food consumption and increases satiety in both normal and obese individuals, presumably by interaction with sensory neurones in the gastrointestinal tract or hepatoportal region (Trapp and Brierley 2022)
The liposomal encapsulation enhances bioavailability, allowing for more efficient absorption in biological systems