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The RBCs of G6PD A- contain only 5% to 15% of the normal amount of enzyme activity and the age-dependent decline of the activity renders old RBCs severely deficient and susceptible to hemolysis

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The compound reliably raised GH and IGF-1, but the two largest or longest trials the Alzheimers study and the two-year healthy-elderly study failed to show benefit on the outcomes that actually matter (cognition/function and strength/function, respectively)