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Oxyberberine (OBB), an important metabolite of BBR, specifically binds hemoglobin, upregulates HO-1 expression in diabetic rats, and improves IR by activating the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) and AMP-activated protein kinase B (AMPK) pathways, which lays the foundation for the translational application of BBR (Dou et al., 2022)