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(2020) demonstrates that GPS treatment effectively triggers apoptosis in these malignant cells (Liu et al., 2020)

In addition, IGL-1+MEL was also shown to reduce vascular resistance probably by a mechanism of e-NOS activation leading to increased of nitric oxide concentration, and to have anti-oxidative and anti-inflammatory effects associated with inhibition of the release of pro-inflammatory cytokines, especially TNF and adiponectin (249)

Response: We thank the commenter for their suggested edit

doi: 10.1038/s41467-022-32368-z 28 XuYLuZLingYHouRTaoJDengGet al

Studies in rare diseases have been very valuable for understanding mechanisms and developing interventions