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Second, time-varying confounding due to informative censoring could be present in as-treated analyses, while an intention-to-treat analysis is not susceptible to treatment-related informative censoring
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but lower doses led to more modest weight loss:Lower doses had a more favourable side effect profile, too:This triple agonism aims to relieve some of the side effects of GLP1s (nausea, muscle loss), and increase weight loss (so the dose can be lowered)Sources: New obesity drugs - nature.com/articles/d4158 Triple agonist Retatrutide phase 2 trial - nejm.org/doi/full/10.10 full article: openread.academy/en/paper/readi Breakdown of the article: The article discusses the development of new obesity drugs that aim to provide greater and healthier weight loss
The glide energy was used to rank the various docking poses and identify the ones that are likely to represent the most favorable binding poses in the protein-ligand complexes
