There is cross-talk between the omega-3 PUFA and the thyroid hormone pathways, as exemplified by the augmented thyroid hormone signaling pathways in the liver, this being one mechanism used by n-3 PUFAs to affect lipid metabolism (108)
Beyond interaction with lipid enzymes, our MS interactome analysis indicates that the GLP-1R binds to ERMCS-localised Sarcoendoplasmic Reticulum Calcium ATPase (SERCA) pump in the ER and voltage-dependent anion-selective channel protein 2 (VDAC2) in the OMM, both involved in calcium/ion transfer across ERMCSs 90 , suggesting a prominent role for the receptor in the control of intra-organelle ion homoeostasis, with important implications for the regulation of mitochondrial function, ER stress responses and insulin secretion 91
This gastric slowdown is not the same as gastroparesis, which is a medical disorder where the stomach loses the ability to contract effectively at all
All patients were recruited late summer and early fall of the same year
doi: 10.2119/molmed.2009.00039 87 LewisEDRichardCGorukSWadgeECurtisJMJacobsRLet al
