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This dual-action mechanism is one reason Mounjaro has gained attention for substantial weight-loss results

134 The role of GLP-1s in the setting of antidepressant medications, which could have both synergistic and opposing benefits and side effects, 135 requires more study

The signal across studies is consistent: in women with PCOS and excess weight, GLP-1 medicines improve metabolic risk and, for many, reproductive parameters

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This effect, already hinted at in the individual serine doublet mutants, contrasts with the increase in cAMP associated with reduced homologous desensitisation of the phospho-null mutant previously observed in a heterologous system (5)