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Identify gaps in the literature and ongoing research directions Key gaps include a lack of large, controlled clinical trials, unclear optimal dosing and delivery for reproductive targets, limited long-term safety data for systemic use, and few mechanistic human studies linking molecular changes to fertility outcomes

While GHK-Cu patients do not have Wilson disease by definition (Wilson disease would be a contraindication), the dietary copper context matters

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The AZIN2 gene is located on chromosome 1p35.1 and is composed of 16 exons that generate 18 alternatively spliced mRNAs that collectively encode six distinct protein isoforms

Walter et al., 1996