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Based on the evidence to date, a low sKlotho level may not represent a useful biomarker for CKD diagnosis and prognosis

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In cases where therapeutic benefits were observed in clinical trials, it often became apparent that these effects were unrelated to the compounds antioxidant activity

Discussion Deficiency of vitamin D (VD) is a significant and most common risk factor for chronic diseases, including insulin resistance, obesity, diabetes, and atherosclerosis 20,21,22,23

Recent studies suggest that senescent glial cells also produce SASP-like molecules