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After stopping a GLP1 the appetite may rise while calories being burned may still be lower, which can make weight regain occur. With even mild weight regain your body might start producing higher levels of insulin again and in return need to start storing more fat again

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It works differently than many currently available treatments because it targets three hormone receptors involved in metabolism and appetite regulation: GLP-1 GIP Glucagon Because of this triple-action mechanism, retatrutide has shown very promising results in early clinical trials, with some participants experiencing significant reductions in body weight