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In high-fat-fed rats, [dA(2)]GLP-1/GcG reduced body weight nonfasting plasma glucose, and boosted circulating plasma insulin concentrations when given twice daily for 21 days

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Due to inadequate insurance coverage, limited availability, and high costs, many people are turning to compounded GLP-1 RAs, which are often cheaper and easier to access but lack standardized efficacy, safety, and dosage information, and their safety profile is largely unknown

Shen-Gunther et al., 2020)

Importantly, the QMP-engineered GLP-1 albumin fusion did not only display improved PK properties, but also demonstrated a prolonged therapeutic effect in healthy human FcRn Tg32 mice challenged with a high dose of glucose