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Disruptions in the dopamine pathway, from its synthesis and release to receptor binding and reuptake, have been implicated in several neuropathological conditions

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When to talk to your provider If you have reached the maximum recommended dose and maintained it for 12 to 16 weeks without achieving at least 5% body weight loss, a conversation with your provider is warranted

For someone on tirzepatide who is adjusting their diet and increasing physical activity, these effects could meaningfully improve body composition outcomes

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