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Hu S, Dan W, Liu J, Ha P, Zhou T, Guo X, et al

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Particles can come from: Degraded peptide forming insoluble aggregates Contamination during manufacturing or storage Rubber stopper fragments from repeated needle punctures Crystallization of dissolved components If you see particles, do not try to filter them out

FIGURE 3 Biological datasets are exceedingly complex and high dimensional as they cover thousands of genes, transcripts, and proteins