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PMID 12834017

However, targeting co-activators may pose certain impediments since they not only play crucial role in disease progression, but also regulate other physiological mechanisms that are necessary for the survival of the organism

10.1016/j.ccep.2015.03.017 44 SlettenA

83,84,85,86,87 NF-B is a transcription factor responsible for improving the transcription of various inflammation-associated proteins, including pro-interleukin-1 (pro-IL-1), when secreted in the extracellular space