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Berberine also restored protein phosphate 2A (PP2A) activity and glycogen synthase kinase 3 (GSK-3) activity (GSK-3 Tyr216 and Ser9 site phosphorylation increased) (Yu et al., 2011)

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The PI3K/Akt axis activated by IGF1R is protective against ischemic injury in cardiac models, and LR3 has been used as a tool in cardioprotection studies, often in conjunction with other research compounds for combined mechanism investigation

Furthermore, it promotes efficient wound healing, accelerating the regeneration of damaged tissues for a smoother recovery process