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Glycyrrhizin alleviates liver injury by precisely inhibiting the overactivation of this pathway in normal hepatocytes, which reverses cell cycle blockade and restores normal hepatocyte proliferation and function through downregulating p53/p21 and upregulating Cyclin D1, all without compromising the antitumor efficacy of gefitinib via the same pathway in cancer cells ( 4.7 Glycyrrhizin and other hepatoprotective agents A variety of hepatoprotective agents are currently used in clinical practice, including silymarin, N-acetylcysteine (NAC), ursodeoxycholic acid (UDCA), as well as polyene phosphatidylcholine (PPC), bicyclol, S-adenosylmethionine (SAMe), and glucocorticoids

Constipation is the most common lower gastrointestinal symptom but can alternate with diarrhea