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Most patients in the ACHIEVE trials who experienced GI symptoms found them manageable, and discontinuation rates due to side effects were in the 5-8% range, similar to injectable alternatives

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The drug must also be used within the Food and Drug Administration (FDA)s scope

Infusion of GLP-1(7-37) (5 pmol/min/kg) from 1 hour through 7 hours produces a sustained increase in plasma insulin concentration relative to levels in rats infused with vehicle in rats with maintained glucose concentration at 11 mM [2]

EFSA Journal, 23 (5), e9371