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The hole left by the needle is microscopic

In the Phase 2 obesity data the weight curve was still trending downward at 48 weeks, so a genuine plateau at a tolerated maintenance dose may simply reflect the body settling toward a new set point rather than the protocol failing

Ann Surg 267(3):514-520, 2018

However, the risks associated with its use are non-trivial, particularly given the lack of regulatory approval and the potential for serious side effects